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KMID : 0352720200440060843
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Journal of Ginseng Research
2020 Volume.44 No. 6 p.843 ~ p.848
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Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
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Baik Ji-Sue
Seo You-Na
Yi Joo-Mi
Rhee Man-Hee
Park Moon-Taek
Kim Sung-Dae
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Abstract
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This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.
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KEYWORD
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Cancer, Ginsenoside-Rp1, Macrophages, Panax ginseng, Radiation
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